Scot Matkovich, PhD, is an Assistant Professor within the Department of Medicine and Center for Cardiovascular Research at Washington University School of Medicine, St Louis, Missouri, USA. He obtained his PhD from the University of Melbourne, under Elizabeth Woodcock at the Baker Medical Research Institute (now the Baker Heart and Diabetes Institute) and was a postdoctoral fellow in the laboratories of Andrew Marks (Columbia University Medical Center, New York City) and Gerald Dorn (University of Cincinnati, Ohio, and Washington University).
His research interests have spanned cardiac calcium signaling, G protein-coupled receptor function, protein kinases and apoptosis, but in the last several years have focused on noncoding RNAs. This has included regulation of microRNAs and their downstream actions in cardiac hypertrophy and failure, but also roles of microRNAs in diabetic cardiomyopathy and in the control of insulin release from pancreatic islets. He has developed novel experimental and computational methods for determining direct microRNA targets in vivo. Through interactions with computational experts, he aims to integrate experimental data into quantitative, predictive networks capable of modeling the effects of perturbing individual RNA molecules, adopting principles of systems biology.
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