Professor Lambiase graduated from Oxford University in 1992 and initially trained in General Medicine and Cardiology at St Georges Hospital, London and the Hammersmith Hospital. He undertook a PhD examining myocardial protection at St Thomas’ Hospital where he was awarded the Young Investigator Award of the British Cardiac Society for his research in 2002. At this stage he also developed an interest in heart failure pacing and was a finalist in the NASPE (North American Society of Pacing and Electrophysiology) Young Investigator competition in the same year. Between 2002-2004 he completed clinical cardiology training at St Thomas’ specialising in arrhythmia treatment (Electrophysiology) and Pacing. He then became the Lecturer in Electrophysiology at The Heart Hospital, UCL where he completed specialist training and initiated the Electrophysiology research programme at the Heart Hospital.
He became a Consultant Cardiologist and Senior Lecturer in Electrophysiology at UCL in 2006 being promoted to Reader in 2012 & Professor of Cardiology in 2015 where he conducts specialist arrhythmia clinics and a nationally recognized clinic studying families with inherited arrhythmia syndromes and SADS (Sudden Arrhythmic Death Syndrome). He received the British Cardiovascular Society Michael Davies Early Career Award in 2015. He is the British Heart Rhythm Society Research Committee Chair & is Chief Investigator for an International Registry of the Subcutaneous ICD.
His research group focuses on ventricular arrhythmogenesis in inherited arrhythmia syndromes including Brugada, long QT syndrome and cardiomyopathic disease. This involves in vivo high density mapping studies of the heart in these patients. The basis of Sudden Arrhythmic Death Syndrome is being studied through clinical and genetic screening of affected families and molecular autopsy. At a more fundamental level, the group is investigating the cellular & molecular basis of arrhythmia in ARVC, long QT and Brugada models(in collaboration with Professor Andrew Tinker, UCL). The in vivo electrodynamics and mechanics of the failing human ventricle are fundamental to the development of ventricular arrhythmia in heart failure patients. This is being investigated using a combination of MR imaging and high density mapping through collaborations with the UCL & KCL imaging sciences groups. Clinical studies also include AF mechanisms and trials of novel ablation strategies versus conventional techniques. Research is supported by project grants and fellowships from MRC, Welcome Trust, BHF, Heart Research UK, Barts Charity and UCL CBRC.
He has co-written Heart Rhythm UK Guidelines on genetic testing and the management of these conditions and published over 130 peer-reviewed papers in Cardiology. He is an Editor of the Oxford Handbook of Inherited Cardiovascular Disease and the Panel Lead for the Royal College of Physicians Map of Medicine Pathways in arrhythmia management & an EHRA Postgraduate Electrophysiology Course Director. He is now Clincial Electrophysiology Research Director at the Barts Heart Centre since the merger of UCLH & Barts Cardiology Services in June 2015.
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